Vaccine

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Context on Vaccine Development

Every Vaccine and Treatment in Development for COVID-19

πŸ”—https://www.visualcapitalist.com/every-vaccine-treatment-covid-19-so-far/
A broad infographices and list of all the vaccine, diagnoses and treatment in pipeline for CCOVID19

General context of vaccine development
οΏ½accine development, testing and regulation
hπŸ”—ttps://www.historyofvaccines.org/content/articles/vaccine-development-testing-and-regulation

The COVID19 vaccine development landscape

πŸ”—https://www.nature.com/articles/d41573-020-00073-5

Early drug discovery and development guidelines for Academic Researchers, Collaborators, and Start-up Companies

πŸ”—https://www.ncbi.nlm.nih.gov/books/NBK92015/
Chapter contains guidelines to develop therapeutic hypotheses, target and pathway validation, proof of concept criteria and generalized cost analyses at various stages of early drug discovery.

Vaccine R&D success rate and development timeline

πŸ”—https://www.semanticscholar.org/paper/Vaccine-R%26D-success-rates-and-development-times-Struck/4df3c24a228178ab24f6e3edc3d80a04c8c8ff0d

Clinical Development Success Rates 2006-2015

πŸ”—https://www.bio.org/sites/default/files/legacy/bioorg/docs/Clinical%20Development%20Success%20Rates%202006-2015%20-%20BIO,%20Biomedtracker,%20Amplion%202016.pdf
Benchmarking report, analyses the clinical development success rates for drug development for a broad range of diseases areas.

Estimating the Cost

An overview of the complexity and cost of vaccine manufacturing
πŸ”—https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518734/

Capacity of vaccine manufacturing

πŸ‡ΊπŸ‡ΈπŸ”—https://www.businessinsider.com/bill-gates-factories-7-different-vaccines-to-fight-coronavirus-2020-4
Gates foundation building manufacturing capacity for parallel development of top 7 vaccine candidates.

Institutional Response for Universal access to vaccine

πŸ‡ΊπŸ‡³WHO

πŸ‡ΊπŸ‡³πŸ”—https://www.who.int/news-room/detail/13-04-2020-public-statement-for-collaboration-on-covid-19-vaccine-development
Public statement for collaboration on COVID-19 vaccine development

European Commission:

πŸ”—https://ec.europa.eu/commission/presscorner/detail/en/ip_20_797
European commission pledge €7.4 billion from donors worldwide for universal access to Covid-19 vaccines

πŸ‡¬πŸ‡§United Kingdom

https://www.gov.uk/government/news/mhra-approves-covid-19-vaccine-trial-in-7-working-days
MHRA approves COVID-19 vaccine trial in 7 working days

Alternative Treatment

πŸ”—https://twitter.com/davidasinclair/status/1238972082756648960
Interesting thread by a Harvard Professor with treatments that seem to work

πŸ”—https://medium.com/@ra.hobday/coronavirus-and-the-sun-a-lesson-from-the-1918-influenza-pandemic-509151dc8065
The sun! a Lesson from the 1918 Influenza Pandemic.

πŸ”— https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371825/
Article on the Potential Impact of Antiviral Drug Use during Influenza Pandemic.

πŸ”—https://apnews.com/a5077c7227b8eb8b0dc23423c0bbe2b2
More deaths, no benefit from malaria drug in VA virus study

Potential limitation

πŸ”—https://science.sciencemag.org/content/367/6485/1405
Underpromise, overdeliver

πŸ”—https://edition.cnn.com/2020/03/27/health/chicken-egg-flu-vaccine-intl-hnk-scli/index.html
The US keeps millions of chickens in secret farms to make flu vaccines. But their eggs won't work for cCronavirus

Scientific Vaccine Development and Related Supporting Research Efforts

πŸ”— https://epitopes.world/en
Open Source results of AI algorithm - 'CAMAP' Research. 'CAMAP' was originally applied to Cancer Immunotherapy. However, as it has learned general patterns about the immune system, CAMAP can also unveil virus weaknesses. And could speed up the discovery of a vaccine against SARS-CoV-2.